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Dexmedetomidine nasal spray for acute severe behavioural disturbance and agitation

Updated: Feb 22

Dexmedetomidine 0.025% intranasal/buccal is now available (physician prescribed) as a first line self or carer administered treatment of an agitated, aggressive or combative patient. (Including Emergency Department, Paramedic, Psychiatry use)

Dexmedetomidine is a highly potent & selective alpha2 agonist which acts to significantly reduce catecholamines and induce a calm & comfortable state (like natural sleepiness) without respiratory depression.

Dexmedetomidine has been used for agitation in ICU for 2 decades. Intranasal/sublingual/buccal administration is safe because initial hypertension and bradycardia is avoided. Plasma concentrations achieved are comparable to an intravenous infusion over 60 minutes.

# Neuropsychiatric, Alzheimer's, Drug intoxications or withdrawals and Undifferentiated causes in the absence of low heart rate, blood pressure or conditions that rely on high sympathetic tone for stability e.g. hypovolaemia and congestive heart failure

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