• emerge_d

Therapeutic Intranasal Drug Delivery.

Updated: Feb 22

Intranasal bioavailability decreases exponentially as atomized volume increases above 100 microliters (0.1 ml) for high first pass metabolism molecules eg midazolam, triazolam, fentanyl, ketamine and dexmedetomidine. Therefore, the key to consistently good intranasal bioavailability is minimal volume and maximum concentration.

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